C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/00 (2006.01) C12N 15/00 (2006.01) C12P 7/64 (2006.01)
Patent
CA 2701094
Engineered strains of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 50 weight percent of eicosapentaenoic acid ["EPA"], an ?-3 polyunsaturated fatty acid, in the total oil fraction are described. These strains over-express heterologous ?9 elongases, ?8 desaturases, ?5 desaturases, ?17 desaturases, ?12 desaturases and C?16/18#191 elongases, and optionally over-express diacylglycerol cholinephosphotransferases. Preferred gene knockouts are also described. Production host cells, methods for producing EPA within said host cells, and products comprising EPA from the optimized Yarrowia lipolytica strains are claimed.
L'invention concerne des souches élaborées de la levure oléagineuse Yarrowia lipolytica capable de produire plus de 50 pour cent en poids d'acide eicosapentaénoïque [= EPA =], un acide gras D3-polyinsaturé, dans la fraction d'huile totale. Ces souches surexpriment des D9-élongases, des D8-désaturases, des D5-désaturases, des D17-désaturases, des D12-désaturases et des C16/18 élongases hétérologues, et surexpriment facultativement des diacylglycérol cholinephosphotransférases. Des éliminations de gène préférées sont également décrites. La production de cellules hôtes, des procédés de production d'EPA dans les cellules hôtes et des produits comportant de l'EPA provenant des souches Yarrowia lipolytica optimisées sont revendiqués.
Xue Zhixiong
Yadav Narendra S.
Zhu Quinn Qun
E. I. Du Pont de Nemours And Company
Torys Llp
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