Thermostable proteins and methods of making and using thereof

Details Thermostable proteins and methods of making and using thereof Thermostable proteins and methods of making and using thereof

C - Chemistry, Metallurgy

07

K

C07K 14/245 (2006.01) C07K 14/00 (2006.01) C12N 15/31 (2006.01) C12P 21/02 (2006.01) G01N 33/53 (2006.01) G01N 33/66 (2006.01)

Patent

CA 2649535

The present invention relates to functional, modified glucose-galactose binding proteins (GGBPs), that have a greater melting temperature (Tm) than a reference GGBP. The present invention also relates to biological sensors, e.g., glucose sensors, comprising these thermostable GGBPs. The present invention also relates to nucleic acids encoding these thermostable GGBPs.

La présente invention concerne des protéines de liaison au glucose/galactose (GGBP) modifiées fonctionnelles dont la température de fusion (Tm) est supérieure à celle d'une GGBP de référence. La présente invention concerne également des biocapteurs, par exemple des capteurs de glucose, comprenant ces GGBP thermostables, ainsi que des acides nucléiques codant pour ces GGBP thermostables.

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