Methods of preparing polymers having terminal amine groups...

Details Methods of preparing polymers having terminal amine groups... Methods of preparing polymers having terminal amine groups...

C - Chemistry, Metallurgy

08

G

C08G 65/333 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2623542

The present invention is directed to methods of preparing linear polymers such as polyalkylene oxides containing a terminal amine in high purity. One preferred method includes reacting a polyalkylene oxide such as polyethylene glycol containing a terminal tosylate with a protected amine salt to form a polymer containing a terminal protected amine and thereafter deprotecting the polymer containing the terminal protected amine to form the polymer having a terminal amine. The resultant polymer-amines are of sufficient purity so that expensive and time consuming purification steps required for pharmaceutical grade polymers are avoided.

L'invention concerne des procédés de préparation de polymères linéaires tels que des oxydes de polyalkylène contenant une amine terminale de haute pureté. Un procédé préféré consiste à faire réagir un oxyde de polyalkylène tel que du polyéthylèneglycol contenant un tosylate terminal avec un sel amine protégé afin de former un polymère contenant une amine protégé terminale, puis à déprotéger le polymère contenant l'amine terminale protégée afin de former le polymère ayant une amine terminale. Les polymères-amines ainsi obtenus présentent une pureté suffisante pour éviter des étapes de purification longues et coûteuses nécessaires pour des polymères de qualité pharmaceutique.

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