Id-1 and id-2 genes and products as diagnostic and...

Details Id-1 and id-2 genes and products as diagnostic and... Id-1 and id-2 genes and products as diagnostic and...

C - Chemistry, Metallurgy

12

Q

C12Q 1/00 (2006.01) A01N 37/18 (2006.01) A01N 43/04 (2006.01) A01N 61/00 (2006.01) C07H 21/04 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2422320

A method for detection and prognosis of breast cancer and other types of cancer. The method comprises detecting expression, if any, for both an Id-1 and an Id-2 genes, or the ratio thereof, of gene products in samples of breast tissue obtained from a patient. When expressed, Id-1 gene is a prognostic indicator that breast cancer cells are invasive and metastatic, whereas Id-2 gene is a prognostic indicator that breast cancer cells are localized and noninvasive in the breast tissue.

L'invention concerne une méthode de détection et de pronostic du cancer du sein et d'autres types de cancer. La méthode consiste à détecter l'expression, le cas échéant, tant pour un gène Id-1 que pour un gène Id-2, ou leur rapport, de produits géniques dans des échantillons de tissu mammaire prélevés chez une patiente. Le gène Id-1, lorsqu'il est exprimé, est un indicateur pronostiquant la présence dans le tissu mammaire de cellules cancéreuses non invasives.

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