Human endokine alpha

Details Human endokine alpha Human endokine alpha

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A61K 39/395 (2006.01) C07K 14/52 (2006.01) C07K 14/525 (2006.01) C07K 16/24 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2264200

The present invention concerns a novel member of the tumor necrosis factor (TNF) family of cytokines. In particular, isolated nucleic acid molecules are provided encoding the endokine alpha protein. Endokine alpha polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic and therapeutic methods concerning TNF family-related disorders.

L'invention se rapporte à un membre nouveau de la famille TNF des cytokines et en particulier à des molécules d'acide nucléique isolées codant la protéine endokine alpha. L'invention concerne également des polypeptides de l'endokine alpha, des vecteurs, des cellules hôtes et des procédés de recombinaison pour les produire. L'invention concerne enfin des méthodes de diagnostic et de thérapie concernant des troubles liés à la famille TNF.

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