A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4178 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61P 9/04 (2006.01) A61P 9/12 (2006.01) A61P 13/12 (2006.01)
Patent
CA 2310028
This invention relates to high drug load granulation of (E)-.alpha.-[2-n-butyl- 1-[(4-carboxyphenyl) methyl]-1H-imidazol-5-yl] methylene-2-thiophenepropionic acid in the anhydrous form, a process for its production, compositions containing the compound and methods of using the compound to block angiotensin II receptors and to treat hypertension, congestive heart failure and renal failure.
L'invention concerne un procédé de granulation à forte dose médicamenteuse d'acide (E)- alpha - [2-n-butyl-1- [(4-carboxyphényl)méthyl]-1H -imidazol-5-yl] méthylène-2- thiophénépropionique sous sa forme anhydre. L'invention concerne également un procédé de production de granules, des compositions contenant ledit composé et des méthodes d'utilisation dudit composé pour bloquer les récepteurs d'angiotensine II et traiter l'hypertension, l'insuffisance cardiaque globale et l'insuffisance rénale.
Glaxosmithkline Llc
Gowling Lafleur Henderson Llp
Smithkline Beecham Corporation
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