Methods for selectively modulating survivin apoptosis pathways

Details Methods for selectively modulating survivin apoptosis pathways Methods for selectively modulating survivin apoptosis pathways

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C12Q 1/37 (2006.01) C12Q 1/48 (2006.01) G01N 33/50 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2401607

The present invention, based on the discovery of a new biological phenomena, provides methods and compositions for use in identifying agents that modulate the phosphorylation of survivin, the interaction between survivin and p34cdc2- cyclin B1 kinase complex, and the interaction between survivin and caspase-9. Related methods and compositions can be used to modulate survivin regulated apoptosis.

L'invention se rapporte à des méthodes et à des compositions qui, suite à la découverte d'un nouveau phénomène biologique, ont permis l'identification d'agents modulant la phosphorylation de la survivine, l'interaction entre la survivine et le complexe kinase p34?cdc2¿-cycline B1, et l'interaction entre la survivine et la caspase-9. L'invention se rapporte à des méthodes et compositions associées qui peuvent être utilisées pour moduler l'apoptose régulée par la survivine.

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