Derivatives of human haemoglobin, method for preparing them,...

Details Derivatives of human haemoglobin, method for preparing them,... Derivatives of human haemoglobin, method for preparing them,...

C - Chemistry, Metallurgy

07

K

C07K 14/805 (2006.01) A61K 38/42 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2076064

Abstract Derivatives of human haemoglobin, method for preparing them, products derived therefrom and use of these deriva- tives and products. The invention relates, as new compounds, to derivatives of tetrameric human haemoglobin corresponding to the covalent coupling of a haemoglobin tetramer and a polycarboxy-substituted compound having at least 4 -COO- groups, the said polycarboxy-substituted compound effect- ing an internal crosslinking of the two dimers of haemo- globin and conferring thereon an affinity for oxygen which is compatible with an in vivo use of the conjugate when the natural allosteric effector of haemoglobin is not present. Among carboxy-substituted compounds, special mention is made of benzenehexacarboxylate and benzene- tetracarboxylate. Figure 2

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