Analgesic composition containing ibuprofen

Details Analgesic composition containing ibuprofen Analgesic composition containing ibuprofen

A - Human Necessities

61

K

A61K 31/19 (2006.01) A61K 9/107 (2006.01) A61K 47/00 (2006.01)

Patent

CA 2060833

The invention provides a topical analgesic composition comprising an oil-in-water emulsion containing about 5% to about 12% by weight of ibuprofen and about 60% to about 90% by weight of water, the oil phase of the emulsion consisting essentially of emollient constituents that do not dissolve the ibuprofen to any great extent at a pH of 4-7, the composition having a pH of about 4 to about 7.2 such that the ibuprofen is suspended in substantially solid crystalline form and the ibuprofen which is dissolved is partially in the neutral or non-charged state. The invention also includes a process for preparing this composition.

Composition analgésique topique composée d'une émulsion huile-eau contenant environ 5 à 12 % en poids d'ibuprofène, et environ 60 à 90 % en poids d'eau, la phase huileuse de l'émulsion consistant essentiellement en constituants émollients qui ne dissolvent pas sensiblement l'ibuprofène à un pH de 4-7; comme la composition a un pH d'environ 4 à 7,2, l'ibuprofène est maintenu en suspension sous forme cristalline sensiblement solide, et la partie qui en est dissoute est partiellement à l'état neutre ou non chargé. L'invention comprend aussi le mode de préparation de cette composition.

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