Methods and compositions for the treatment of polycystic...

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2564092

This invention provides compositions and methods to diagnose and treat polycystic disorders by inhibiting the biological activity of a gene now correlated with appearance of this disorder. By way of illustrative only, the Connective Tissue Growth Factor (CTGF) gene is an example of such a gene. Also provided by this invention are compositions and methods to treat or ameliorate abnormal cystic lesions and diseases associated with the formation of cysts in tissue. The methods and compositions treat and ameliorate pathological cyst formation in tissue by inhibiting or augmenting gene expression or the biological activity of its gene expression product or its receptor.

Cette invention concerne des compositions et des procédés servant à diagnostiquer et à traiter des troubles polykystiques, en inhibant l'activité biologique d'un gène se trouvant alors en corrélation avec l'apparition de ce trouble. A titre d'exemple uniquement, le gène appelé facteur de croissance du tissu conjonctif (CTGF) peut constituer un tel gène. Cette invention concerne également des compositions et des procédés servant à traiter ou à soulager les lésions et maladies avec anomalies kystiques associées à la formation de kystes dans des tissus. Ces procédés et ces compositions traitent et réduisent la formation de kystes pathologiques dans un tissu, en inhibant ou en augmentant l'expression génique ou l'activité biologique de son produit d'expression génique ou de son récepteur.

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