A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/195 (2006.01) A61K 31/34 (2006.01) A61K 31/353 (2006.01) A61K 31/415 (2006.01) A61K 31/421 (2006.01) A61K 31/444 (2006.01) A61K 31/50 (2006.01) A61K 31/522 (2006.01) A61K 31/5415 (2006.01) A61K 31/662 (2006.01) A61K 31/675 (2006.01) A61K 31/706 (2006.01) A61K 45/06 (2006.01) A61P 31/22 (2006.01)
Patent
CA 2510445
The present invention provides compositions and methods for the treatment of herpes virus infections. In one aspect, the invention provides a combination therapy for treating a herpes virus infection comprising the administration to a subject of an anti-herpes virus agent in combination with a cyclooxygenase-2 selective inhibitor. In another aspect, the invention provides a mono therapy for treating a herpes virus infection comprising administering a cyclooxygenase-2 selective inhibitor to a subject. Preferably, the cyclooxygenase-2 selective inhibitor is selected from the group consisting of celecoxib, deracoxib, valdecoxib, rofecoxib, lumiracoxib, etoricoxib, parecoxib, 2-(3,4-difluoro-phenyl)-4-(3-hydroxy-3-methylbutoxy)-5-'4- (methylsulphonyl) phenyl!-3(2H)-pyridazinone, and (S)-6,8-dichloro-2- (trifluoromethyl)-2H-1-benzopyran-3-carboxylic acid; and the anti-herpes virus agent selected from the group consisting of ganciclovir, foscarnet, cidofovir, acycloguanosine, tri-fluorothymidine, acyclovir, famciclovir, and valaciclovir.
La présente invention concerne des compositions et des techniques de traitement des infections par le virus de l'herpès. Dans un aspect, cette invention concerne une thérapie de combinaison de traitement d'une infection par le virus de l'herpès qui consiste à administrer à un sujet un agent antivirus de l'herpès en combinaison avec un inhibiteur sélectif de cyclo-oxygènase-2. Dans un autre aspect, cette invention concerne une monothérapie destinée à traiter une infection par le virus de l'herpès qui consiste à administrer à un patient un inhibiteur sélectif de cyclo-oxygènase-2..
Maziasz Timothy
Pharmacia Corporation
Smart & Biggar
LandOfFree
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