Controlled release metformin compositions

A - Human Necessities – 61 – K

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A61K 31/155 (2006.01) A61K 9/00 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2427195

A composition and methods thereof for treating patients having non-insulin- dependent diabetes mellitus (NIDDM) by administering a controlled release oral solid dosage form containing preferably a biguanide drug such as metformin, on a once-a-day basis. The dosage form provides a mean time to maximum plasma concentration (Tmax) of the drug which occurs at 5.5 to 7.5 hours after oral administration on a one-a-day basis to human patients. Preferably, the dose of drug is administered at dinnertime to a patient in the fed state.

L'invention porte sur une composition et le procédé associé de traitement de patients souffrant du diabète sucré non insulinodépendant par administration par voie orale de formes posologiques solides contenant de préférence des biguanides tels que la metformine, à raison d'une dose par jour. La forme posologique permet une concentration plasmatique, moyenne à maximale, 5,5 à 7,5 heures après l'administration orale d'une dose quotidienne à des patients. Ladite dose s'administre de préférence à jeun à l'heure du dîner.

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