Estrogen receptor

Details Estrogen receptor Estrogen receptor

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/00 (2006.01) C07K 14/705 (2006.01) C07K 14/72 (2006.01) C12N 5/10 (2006.01) C12N 5/16 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) G01N 33/74 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2302629

This invention relates to a novel estrogen receptor and to the polynucleotide sequences encoding this receptor. This invention also relates to methods for identifying ligands which bind to this receptor, to the ligands so identified, and to pharmaceutical compositions comprising such ligands. This invention also relates to pharmaceutical compositions useful for treating or preventing estrogen receptor mediated diseases or conditions, such as abnormal bone resorption, cardiovascular diseases, cancer, or central nervous system disorders.

L'invention concerne un nouveau récepteur d'oestrogène et aux séquences polynucléotidiques le codant. Elle porte aussi sur des procédés d'identification de ligands qui se fixent à ce récepteur, aux ligands ainsi identifiés et à des compositions pharmaceutiques comprenant lesdits ligands. Elle se rapporte encore à des compositions pharmaceutiques utiles pour le traitement ou la prévention de maladies ou d'états induits par les récepteurs d'oestrogène, comme la résorption osseuse anormale, les maladies cardio-vasculaires, le cancer, ou les troubles du système nerveux central.

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