C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/09 (2006.01) A61K 38/06 (2006.01) A61P 25/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2465245
The present invention relates to biologically active peptides derived from the neurite outgrowth-promoting domain of laminin-1, i.e. the .gamma.1-chain of laminin-1. These peptides include the decapeptide RDIAEIIKDI and the truncated peptides derived therefrom comprising the biologically active domain thereof, the tripeptide KDI. The invention is directed to the biologically active tripeptide motif KDI, and to its use in promoting regeneration of neuronal or non-neuronal tissues and, in specific, to its use in the treatment of spinal cord injuries.
La présente invention concerne des peptides actifs biologiquement dérivés du domaine de promotion d'excroissance de neurites de laminine-1, c'est-à-dire la chaîne .gamma.-1 de laminine-1. Ces peptides comprennent le décapeptide RDIAEIIKDI et les peptides tronqués dérivés contenant le domaine actif biologiquement correspondant, le tripeptide KDI. Cette invention a également trait au motif KDI du tripeptide actif biologiquement et à son utilisation dans la promotion de la régénération des tissus neuronaux ou non neuronaux, et, notamment, à son utilisation dans le traitement de traumatismes médullaires.
Liesi Paeivi
Mccarthy Tetrault Llp
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