C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 69/34 (2006.01) B01J 31/24 (2006.01) C07B 53/00 (2006.01) C07C 231/18 (2006.01) C07C 233/04 (2006.01) C07D 319/04 (2006.01) C07D 319/20 (2006.01) C07D 407/02 (2006.01) C07D 487/08 (2006.01) C07D 493/06 (2006.01) C07F 9/02 (2006.01) C07F 9/28 (2006.01) C07F 9/50 (2006.01) C07F 9/553 (2006.01) C07F 9/572 (2006.01) C07F 9/6506 (2006.01) C07F 9/655 (2006.01) C07F 9/6561 (2006.01) C07F 9/6596 (2006.01) C07C 233/05 (2006.01) C07C 233/13 (2006.01) C07C 233/18 (2006.01)
Patent
CA 2390998
Chiral ligands and transition metal complexes based on such chiral ligands useful in asymmetric catalysis are disclosed. The chiral ligands include (R,S,S,R)-DIOP*. The ruthenium complex reduces enamide to the corresponding amine with up to 99% enantioselectivity. The transition metal complexes of the chiral ligands are useful in asymmetric reactions such as asymmetric hydrogenation, hydride transfer, hydrosilylation, hydroboration, hydrovinylation, hydroformylation, hydrocarboxylation, isomerization, allylic alkylation, cyclopropanation, Diels-Alder reaction, Heck reaction, isomerization, Aldol reaction, Michael addition and epoxidation reactions.
L'invention concerne des ligands chiraux et des complexes de métaux de transition formés avec ces ligands chiraux, qui sont utiles dans la catalyse des réactions asymétriques. Ces ligands chiraux comprennent (R,S,S,R)-DIOP*. Le complexe ruthénium réduit l'énamide en amine correspondante avec une énantiosélectivité pouvant atteindre 99 %. Les complexes de métaux de transition de ces ligands chiraux sont utiles dans les réactions asymétriques telles que l'hydrogénation, le transfert d'hydrure, l'hydrosilylation, l'hydroboration, l'hydrovinylation, l'hydroformylation, l'hydrocarboxylation, l'isomérisation, l'alkylation allylique, la cyclopropanation, la réaction de Diels-Alder, la réaction de Heck, l'isomérisation, la réaction d'aldol, l'addition de Michael et les réactions d'époxidation asymétriques.
Zhang Xumu
Sim & Mcburney
The Penn State Research Foundation
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