Inhibitors of prenyl-protein transferase

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 209/12 (2006.01) A61K 31/4045 (2006.01) C07D 209/18 (2006.01) C07D 401/06 (2006.01) C07D 405/12 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2424222

The present invention is directed to fused bicyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.

La présente invention se rapporte à des composés bicycliques fondus qui inhibent la prényl-protéine transférase et la prénylation de la protéine oncogène Ras. Cette invention concerne également des compositions chimiothérapeutiques contenant les composés de ladite invention ainsi que des procédés pour inhiber la prényl-protéine transférase et la prénylation de la protéine oncogène Ras.

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