Use of anthocyanidin and derivatives for treatment of...

Details Use of anthocyanidin and derivatives for treatment of... Use of anthocyanidin and derivatives for treatment of...

A - Human Necessities

61

K

A61K 31/70 (2006.01)

Patent

CA 2202467

The invention relates to the use of an anthocyanidin or an anthocyanidin derivative of general formula (I) wherein R1, R2, R3 and R6 independently of each other is H, OH, alkoxy, an -O-glycosyl group, an -O-glycosyl group which is substituted with one or more acyl groups, or an -O-glycosyl moiety comprising at least two glycosyl groups and at least one acyl group arranged so that at least one acyl group is located between two glycosyl groups, R4 is OH, alkoxy, an -O-glycosyl group, an -O-glycosyl group which is substituted with one or more acyl groups, or an -O-glycosyl moiety comprising at least two glycosyl groups and at least one acyl group arranged so that at least one acyl group is located between two glycosyl groups, R5 is H, OH, and Y is a counterion or a salt, prodrug or complex thereof for the preparation of a pharmaceutical composition for the prevention and/or treatment of retroviral infections in mammals, as well as to novel anthocyanidin derivatives of general formula (I) and methods for preparation of said compounds and novel pharmaceutical compositions.

Utilisation d'une anthocyanidine ou d'un dérivé d'anthocyanidine répondant à la formule générale (I), dans laquelle R¿1?, R¿2?, R¿3? et R¿6? indépendamment les uns des autres, représentent H, OH, alcoxy, un groupe -O-glycosyle, un groupe -O-glycosyle substitué par un ou plusieurs groupes acyles, ou une fraction -O-glycosyle comportant au moins deux groupes glycosyles et au moins un groupe acyle disposés de telle sorte qu'au moins un groupe acyle se situe entre deux groupes glycosyles; R¿4? représente OH, alcoxy, un groupe -O-glycosyle substitué par un ou plusieurs groupes acyles, ou une fraction -O-glycosyle comportant au moins deux groupes glycosyles et au moins un groupe acyle disposés de telle sorte qu'au moins un groupe acyle se situe entre deux groupes glycosyles; R¿5? représente H ou OH; et Y représente un contre-ion ou un sel, promédicament ou complexe de celui-ci; dans la préparation d'une composition pharmaceutique destinée à la prophylaxie et/ou au traitement des infections rétrovirales chez les mammifères. On a également prévu de nouveaux dérivés d'anthocyanidine répondant à la formule générale (I), et des procédés de préparation de ces composés et de nouvelles compositions pharmaceutiques.

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