C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 473/00 (2006.01) A61K 31/52 (2006.01) A61K 31/535 (2006.01) C07D 473/18 (2006.01) C07D 473/20 (2006.01) C07D 473/24 (2006.01) C07D 473/34 (2006.01)
Patent
CA 2165433
Novel purine derivatives and their isoguanine and dithioxanthine precursor compounds are disclosed. These compounds have bronchial and tracheal relaxation and/or anti-inflammatory activity. The invention is also related to processes for their preparation, to pharmaceutical compositions containing them and to their medical use. In certain preferred embodiments, the invention relates to 3-substituted and 3,8- disubstituted 6-amino purine derivatives. .
On décrit de nouveaux dérivés de purine et leurs composés précurseurs à base d'isoguanine et de dithioxanthine. Ces composés présentent une activité de relaxation bronchique et trachéale et/ou anti-inflammatoire. L'invention concerne aussi leurs procédés de préparation, des compositions pharmaceutiques les contenant et leur utilisation médicale. Dans certaines variantes préférées, l'invention concerne des dérivés de 6-amino purine 3-substitués et 3,8 disubstitués.
Cavalla David
Chasin Mark
Gehrig Andre
Hofer Peter
Wintergerst Peter
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Euro-Celtique S.a.
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