Antibodies that immunospecifically bind to blys

Details Antibodies that immunospecifically bind to blys Antibodies that immunospecifically bind to blys

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) C07K 14/52 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) G01N 33/564 (2006.01)

Patent

CA 2407910

The present invention relates to antibodies and related molecules that immunospecifically bind to BLyS. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant BLyS expression or inappropriate function of BLyS comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to BLyS. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant BLyS expression or inappropriate BLyS function comprising administering to an animal an effective amount of oune or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to BLyS.

L'invention concerne des anticorps et des molécules associées se liant de manière immunospécifique à un stimulateur de lymphocyte B (BLyS). L'invention concerne également des méthodes et des compositions permettant de détecter ou de diagnostiquer une maladie ou un trouble associé à une expression aberrante de BLyS ou à une fonction inappropriée de BlyS, qui comprennent des anticorps, des fragments ou des variants de ceux-ci, ou des molécules associées qui se lient de manière immunospécifique à BLyS. L'invention concerne enfin des méthodes et des compositions permettant d'empêcher, de traiter, ou de soulager une maladie ou un trouble associé à une expression aberrante de BLyS ou à une fonction inappropriée de BlyS. Ces méthodes consistent à administrer à un animal une quantité efficace d'au moins un anticorps, un fragment ou un variant de celui-ci, ou des molécules associées qui se lient de manière immunospécifique à BLyS.

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