A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/48 (2006.01) A61K 38/17 (2006.01) A61P 35/00 (2006.01) C07K 14/435 (2006.01) C12N 9/68 (2006.01) C12P 21/02 (2006.01) C12N 15/57 (2006.01)
Patent
CA 2362330
The present invention relates to one or more compositions that inhibit the proliferation and/or migration of endothelial cells. The compositions contain a pre-activation domain ("PAD") from plasminogen (or biologically active fragment thereof) and said at least one kringle region from plasminogen (or biologically active portion thereof). The compositions are useful to treat angiogenic associated disorders.
La présente invention concerne une ou plusieurs compositions inhibant la prolifération et/ou la migration de cellules endothéliales. Les compositions contiennent un domaine de préactivation ("DPA") du plasminogène (ou un fragment bioactif de celui-ci) et au moins ladite région de boucle du plasminogène (ou une partie bioactive de celui-ci). Les compositions sont utiles pour traiter des troubles de type angiogénique.
Ji Wei-Dong-Richard
Kondri Mohammad Eghtedarzadeh
Trail Pamela A.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
LandOfFree
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