Pharmaceutical composition for diagnosis, prevention or...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/47 (2006.01) A61K 31/713 (2006.01) A61K 38/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2450845

The invention relates to a pharmaceutical composition in the field of oncology, for diagnosis, prevention or treatment of a tumorous state, said pharmaceutical composition comprising an active agent capable of stabilising the actin network of the cellular cytoskeleton, in particular a DNA, coding for the zyxin gene. The invention also relates to a method for identification of compounds capable of stabilising the actin network of the cellular cytoskeleton and, furthermore, a diagnostic method for a tumorous state and a method for analysing the tumoral phenotype of a patient, based on quantification of the expression of zyxin by the cells.

La présente invention concerne le domaine de la cancérologie, elle se rapporte à une composition pharmaceutique pour le traitement, la prévention ou le diagnostic d'une pathologie tumorale, ladite composition pharmaceutique comprenant un agent actif capable de stabiliser le réseau d'actine du cytosquelette cellulaire, notamment un AND codant pour le gène de la zyxine. Elle concerne aussi une méthode d'identification de composés capables de stabiliser le réseau d'actine du cytosquelette d'une cellule. L'invention se rapporte également à une méthode de diagnostic d'une pathologie tumoral et à une méthode d'analyse d'un phénotype tumoral d'un patient, basées sur quantification de l'expression de la zyxine par des cellules.

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