A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) C07K 7/00 (2006.01) C07K 14/47 (2006.01)
Patent
CA 2500731
An isolated nucleostemin polypeptide is disclosed herein. The nucleostemin polypeptide includes an amino acid sequence at least 85% identical to SEQ ID NO:2. In several examples, the polypeptide regulates cell differentiation, cell proliferation, or both. Nucleic acids encoding these polypeptides, vectors including the nucleic acids, and host cells transfected with these nucleic acids are also disclosed. Methods for inducing differentiation, inhibiting proliferation, and inducing senescence of a cell by altering the level of a nucleostemin polypeptide including an amino acid sequence at least 80% identical to SEQ ID NO: 2 are also disclosed. Methods for screening for agents that affect proliferation, differentiation. Or senescence of cells are also disclosed.
La présente invention concerne un polypeptide de nucléostemine isolé. Ce polypeptide comprend une séquence d'acides aminés identique à 85% au moins à SEQ ID NO:2. Dans plusieurs exemples, le polypeptide régule la différenciation cellulaire, la prolifération cellulaire, ou les deux. Cette invention concerne également des acides nucléiques codant pour ces polypeptides, des vecteurs comprenant ces acides nucléiques, et des cellules hôtes transfectées avec ces acides nucléiques. L'invention concerne des méthodes permettant d'induire la différenciation, d'inhiber la prolifération et d'induire la sénescence d'une cellule par modification du niveau d'un polypeptide de nucléostémine contenant une séquence d'acides aminés identique à 80% au moins à SEQ ID NO: 2. En outre, cette invention concerne des méthodes permettant des cribler des agents affectant la prolifération, la différentiation, ou la sénescence des cellules.
Mckay Ronald D. G.
Tsai Robert Y. L.
Smart & Biggar
The Government Of The United States Of America As Represented By
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