Affinity selection of ligands by mass spectroscopy

Details Affinity selection of ligands by mass spectroscopy Affinity selection of ligands by mass spectroscopy

G - Physics

01

N

G01N 33/53 (2006.01) G01N 33/538 (2006.01) H01J 49/26 (2006.01)

Patent

CA 2209988

Compounds are quickly selected from a combinatorial library by contacting the library with a target (e.g., receptor), separating non-binding compounds from compound-target complexes, and analyzing the complexes or eluted compound by mass spectroscopy. SAR information is obtained by performing this selection at two or more different ratios of compound to target.

On sélectionne rapidement des composés dans une banque combinatoire en mettant en contact la banque avec une cible (p.ex., un récepteur), en séparant des composés non liant des complexes composés-cibles et en analysant les complexes ou le composé élué par spectroscopie de masse. On obtient des informations sur les relations d'activités structurelles en effectuant cette sélection selon au moins deux rapports différents composé/cible.

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