Substituted piperazine derivatives, the preparation thereof...

Details Substituted piperazine derivatives, the preparation thereof... Substituted piperazine derivatives, the preparation thereof...

C - Chemistry, Metallurgy

07

D

C07D 295/14 (2006.01) A61K 31/496 (2006.01) A61P 3/06 (2006.01) C07D 207/335 (2006.01) C07D 213/38 (2006.01) C07D 213/74 (2006.01) C07D 233/54 (2006.01) C07D 235/18 (2006.01) C07D 239/42 (2006.01) C07D 241/04 (2006.01) C07D 241/20 (2006.01) C07D 263/48 (2006.01) C07D 277/28 (2006.01) C07D 295/145 (2006.01) C07D 295/15 (2006.01) C07D 317/66 (2006.01) C07D 333/20 (2006.01) C07D 333/36 (2006.01)

Patent

CA 2382311

The invention relates to substituted piperazine derivatives of general formula (I), wherein Ra to Re and n have the meaning defined in claim 1. The invention also relates to the isomers and salts of said substituted piperazine derivatives, especially to their physiologically acceptable salts which represent valuable inhibitors of microsomal triglyceride transfer protein (MTP), the medicaments containing said compounds, their utilization and the production thereof.

L'invention concerne des dérivés de pipérazine substitués de formule générale (I) dans laquelle R¿a? à R¿e? et n sont définis comme dans la revendication 1. L'invention concerne également leurs isomères et leurs sels, en particulier leurs sels physiologiquement tolérables qui constituent des inhibiteurs précieux de la protéine de transfert de triglycéride microsomale (MTP). L'invention concerne enfin les médicaments contenant ces composés, leur utilisation et leur fabrication.

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