Substituted tetrahydroisoquinolines as c5a receptor modulators

Details Substituted tetrahydroisoquinolines as c5a receptor modulators Substituted tetrahydroisoquinolines as c5a receptor modulators

C - Chemistry, Metallurgy

07

D

C07D 217/04 (2006.01) A61K 31/47 (2006.01) C07D 211/14 (2006.01) C07D 211/70 (2006.01) C07D 217/14 (2006.01) C07D 221/20 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 403/04 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 405/04 (2006.01) C07D 417/12 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2479930

Substituted tetrahydroisoquinolines of Formula I are provided. Such compounds are ligands that may be used to modulate C5a receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological C5a receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

L'invention concerne des tétrahydroisoquinoléines substituées et leurs composés associés. De tels composés sont des ligands que l'on peut utiliser pour moduler l'activité du récepteur C5a in vivo ou in vitro et conviennent particulièrement au traitement de pathologies associées à l'activation du récepteur C5a pathologique chez les humains, les animaux domestiques et le bétail. L'invention concerne également des compositions pharmaceutiques et leurs procédés d'utilisation dans le traitement de tels troubles, notamment les procédés d'utilisation de tels ligands dans l'analyse de la localisation du récepteur.

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