Methods for protecting allogeneic islet transplant using...

Details Methods for protecting allogeneic islet transplant using... Methods for protecting allogeneic islet transplant using...

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61K 31/436 (2006.01) A61K 35/14 (2006.01) A61K 39/395 (2006.01) A61K 45/06 (2006.01) A61P 3/10 (2006.01) C07K 14/705 (2006.01) C07K 14/725 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2447921

The present invention is a method of inhibiting islet cell transplant rejection paricular, to treat diabetes, such as type-1 and type-2 diabetes, by administering to a subject an effective amount of a soluble CTLA4 mutant molecule. One example of soluble CTLA4 mutant molecule is L104EA29YIg.

La présente invention concerne un procédé permettant d'inhiber le rejet d'une greffe de cellules sécrétrices d'insuline, en particulier pour traiter le diabète, tel que le diabète insulino-dépendant et le diabète non insulino-dépendant, consistant à administrer à un sujet une dose efficace d'une molécule mutante CTLA4 soluble. Un exemple de molécule mutante CTLA4 comprend la molécule L104EA29YIg.

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