A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/00 (2006.01) A01N 37/36 (2006.01) A61K 31/19 (2006.01) A61K 31/195 (2006.01) A61K 31/35 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) A61K 31/59 (2006.01) A61K 33/02 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01)
Patent
CA 2566861
The invention involves the treatment, prevention, and reduction of immunoinflammatory disorders involving the combination of an agent that increases the signal activity of a glucocorticoid receptor (e.g., glucocorticoid receptor agonist) and an agent that modulates the signaling activity of one or more signaling pathways selected from the NF-.kappa.B pathway, NFAT pathway, AP-1 pathway, and Elk-1 pathway such that proinflammatory cytokine secretion or production, or any other inflammatory response, is reduced. Further, screening methods are provided for identifying candidate compounds and strategies useful for treating, preventing, or reducing such conditions.
L'invention concerne le traitement, la prévention et la réduction de troubles immuno-inflammatoires et consistant à combiner un agent augmentant l'activité du signal d'un récepteur glucocorticoïde (par exemple, un agoniste du récepteur glucocorticoïde) et un agent modulant l'activité de signalisation d'une ou plusieurs voies de signalisation sélectionnées parmi les voies : NF-?B, NFAT, AP-1 et Elk-1, de manière que la sécrétion ou production de cytokines pro-inflammatoires ou une autre réponse inflammatoire quelconque soit réduite. De plus, l'invention concerne des procédés de balayage permettant d'identifier des composés candidats et des stratégies utiles dans le traitement, la prévention ou la réduction de tels états.
Jost-Price Edward Roydon
Keith Curtis
Manivasakam Palaniyandi
Staunton Jane
Combinatorx Incorporated
Smart & Biggar
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