Connective tissue derived polypeptides

Details Connective tissue derived polypeptides Connective tissue derived polypeptides

A - Human Necessities

61

K

A61K 38/39 (2006.01) A61P 19/02 (2006.01)

Patent

CA 2528235

The present invention relates to compositions comprising one or more connective tissue derived polypeptides having a molecular weight of less than 30,00ODa which are capable of tolerising individuals to antigenic components of cartilage and prevent the appearance of symptoms of arthritis. The present invention provides methods for recovering polypeptides having a molecular weight of less than 30,00ODa from connective tissue and having anti-arthritic or anti-inflammatory activity. The present invention further relates to compositions comprising a polypeptide comprising a collagen type IX alpha (1) chain NC4 domain or biologically active fragment having anti-arthritic or anti- inflammatory activity and a molecular weight of less than 30,00ODa, which is capable of tolerising individuals to antigenic components of cartilage and prevent the appearance of symptoms of arthritis.

L'invention concerne des compositions comprenant un ou plusieurs polypeptides dérivés de tissu conjonctif possédant un poids moléculaire inférieur à 30000 Da, ces compositions permettant d'induire chez des individus une tolérance à des composants antigéniques de cartilage et d'empêcher l'apparition de symptômes d'arthrite. L'invention concerne en outre des procédés d'obtention de polypeptides possédant un poids moléculaire inférieur à 30000 Da à partir de tissu conjonctif et présentant une activité antiarthritique ou anti-inflammatoire. L'invention concerne par ailleurs des compositions contenant un polypeptide comprenant un domaine NC4 de la chaîne alpha 1 du collagène de type IX ou un fragment biologiquement actif présentant une activité antiarthritique ou anti-inflammatoire et possédant un poids moléculaire inférieur à 30000 Da, ces compositions permettant d'induire chez des individus une tolérance à des composants antigéniques de cartilage et d'empêcher l'apparition de symptômes d'arthrite.

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