Use of paclitaxel and steroid derivatives as aromatase...

Details Use of paclitaxel and steroid derivatives as aromatase... Use of paclitaxel and steroid derivatives as aromatase...

A - Human Necessities

61

K

A61K 31/565 (2006.01) A61K 31/337 (2006.01) A61K 31/566 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2376067

There is provided use of a material selected from (i) microtubule stabilising agent; (ii) microtubule disrupter; (iii) a compound of the formula A-B wherein A is an oxyhydrocarbyl group and B is a cyclic group; and (iv) a compound of the formula C-D wherein C is a sulphamate group and D is a cyclic group, for the manufacture of a medicament for the inhibition of tumour necrosis factor .alpha. (TNF.alpha.) stimulated aromatase activity.

L'invention concerne l'utilisation d'un matériau sélectionné parmi (i) un stabilisant de microtubule; (ii) un perturbateur de microtubule; (iii) un composé représenté par la formule A-B, dans laquelle A représente un groupe oxyhydrocarbyle et B représente un groupe cyclique; et (iv) un composé représenté par la formule C-D, dans laquelle C représente un groupe sulfamate et D représente un groupe cyclique. Un tel matériau est utilisé pour la fabrication d'un médicament permettant d'inhiber l'activité de l'aromatase stimulée par le facteur de nécrose des tumeurs .alpha. (TNF.alpha.).

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