Substance delivery to skin and other tissues

Details Substance delivery to skin and other tissues Substance delivery to skin and other tissues

C - Chemistry, Metallurgy

09

J

C09J 139/06 (2006.01) A61K 9/00 (2006.01) A61K 9/70 (2006.01) A61L 15/44 (2006.01) A61L 15/58 (2006.01) A61M 35/00 (2006.01) A61M 37/00 (2006.01)

Patent

CA 2735418

A pressure-sensitive adhesive composition and an adherent coating composition are described having a reservoir of medication or other substance and capable of intimate contact with a target area of skin or other tissue, respectively, and rapid conveyance of the medication onto and/or into the target area. The adhesive composition is readily removed from the area of skin using water. Mixtures containing polyvinylpyrrolidone and glycerol have been found to dissolve a large number of medications while producing a self-tackifying, pressure-sensitive adhesive composition, or a brushable and/or sprayable adherent film, depending on the mixture. With the addition of a colorant, the extent of coverage and an estimate of the amount of adherent film delivered may be obtained. Application of the adherent film to provide anti- cancer medication to exposed tissue resulting from tumor resection is also described.

L'invention porte sur une composition adhésive sensible à la pression et sur une composition de revêtement adhérent qui comportent un réservoir de médicament ou dautres substances et sont aptes à assurer un contact intime avec respectivement une zone de peau cible ou d'autres tissus ainsi quun transport rapide du médicament sur et/ou dans la zone cible. La composition adhésive est facilement éliminée de la zone de peau à l'aide d'eau. Il a été établi que des mélanges contenant du polyvinylpyrrolidone et du glycérol dissolvent un grand nombre de médicaments tout en produisant une composition adhésive sensible à la pression et donnant delle-même du collant, ou un film adhérent brossable et/ou pulvérisable, en fonction du mélange. Laddition d'un colorant permet de déterminer l'étendue de couverture et dobtenir une estimation de la quantité de film adhérent administré. Linvention porte également sur l'application du film adhérent dans le but dadministrer un médicament anticancéreux à un tissu exposé par suite d'une résection de tumeur.

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