Difluorinated tripeptides as hcv serine protease inhibitors

Details Difluorinated tripeptides as hcv serine protease inhibitors Difluorinated tripeptides as hcv serine protease inhibitors

C - Chemistry, Metallurgy

07

K

C07K 5/08 (2006.01) A61K 38/06 (2006.01) A61P 31/14 (2006.01) C07D 225/00 (2006.01) C07K 5/083 (2006.01) C07K 5/107 (2006.01) C07K 7/06 (2006.01)

Patent

CA 2713005

The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis c virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis c virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

La présente invention concerne des composés représentés par la Formule I, ou un sel de qualité pharmaceutique, un ester ou un promédicament de ceux-ci, qui inhibent l'activité sérine protéase, en particulier l'activité de la protéase NS3-NS4A du virus de l'hépatite C (VHC). Par conséquent, les composés de la présente invention interfèrent avec le cycle de vie du virus de l'hépatite C et s'utilisent également comme agents antiviraux. La présente invention concerne en outre des compositions pharmaceutiques comportant les composés susmentionnés pour une administration à un sujet souffrant d'une infection par le VHC. L'invention concerne également des procédés de traitement d'une infection par le VHC chez un sujet par l'administration d'une composition pharmaceutique comportant les composés de la présente invention.

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