Reverse phase protein array, protein activation and...

Details Reverse phase protein array, protein activation and... Reverse phase protein array, protein activation and...

C - Chemistry, Metallurgy

40

B

C40B 40/00 (2006.01) G06F 19/20 (2011.01) C40B 30/00 (2006.01) C40B 30/02 (2006.01) C40B 40/10 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2653398

Protein activation and expression signatures and methods of obtaining and using protein activation and expression signatures for cancer classification, prognosis, and therapy guidance are provided. A protein activation and expression signature may be formed by a process comprising: assaying a plurality of samples with a protein array; clustering the assayed samples based on patterns; and generating a heat map.

La présente invention concerne les signatures d'activation et d'expression de protéines ainsi que des procédés d'obtention et d'utilisation de telles signatures d'activation et d'expression de protéines aux fins de classification, de pronostic et d'encadrement thérapeutique pour le cancer. Une signature d'activation et d'expression de protéines peut être formée au moyen d'un processus qui consiste à analyser une pluralité d'échantillons avec un réseau protéique, à grouper les échantillons analysés sur la base de modèles et à générer une carte thermique.

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