A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 41/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2605617
A method for destroying harmful cells is provided, applicable in treating proliferative diseases. The cells are destroyed by a combined treatment with a chemiluminescent agent and with a ligand-photosensitizer conjugate. The chemiluminescent agent emits light on reacting with oxygen species present in situ, the conjugate binds to the cell through its ligand and is activated by the emitted light, thereby destroying the cell. The method is demonstrated on a conjugate of transferrin-hematoporphyrin, which destroys cancerous cells in the presence of luminol.
L'invention concerne un procédé de destruction de cellules nocives, applicable au traitement de maladies prolifératives. Lesdites cellules sont détruites par un traitement combiné utilisant un agent chimioluminescent et un conjugué ligand-photosensibilisant. L'agent chimioluminescent émet une lumière lors de la réaction avec une espèce d'oxygène présente in situ, le conjugué se lie à la cellule par l'intermédiaire de son ligand et est activé par la lumière émise, détruisant ainsi la cellule. Dans un mode de réalisation du procédé, on utilise un conjugué transferrine-hématoporphyrine, lequel détruit les cellules cancéreuses en présence de luminol.
Firer Michael A.
Laptev Raisa
Ariel-University Research And Development Company Ltd.
Integral Ip
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