Human vascular endothelial growth factor 2

Details Human vascular endothelial growth factor 2 Human vascular endothelial growth factor 2

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 31/7088 (2006.01) A61K 38/18 (2006.01) A61K 39/235 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/475 (2006.01) C07K 16/22 (2006.01) C12N 15/63 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2413012

Disclosed is a human VEGF2 polypeptide and DNA (RNA) encoding such VEGF2 polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist against such polypeptide. Also disclosed is a method of using such polypeptide for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antagonists to inhibit tumor growth, inflammation and to treat diabetic retinopathy, rheumatoid arthritis and psoriasis. Diagnostic methods for detecting mutations in the VEGF2 coding sequence and alterations in the concentration of VEGF2 protein in a sample derived from a host are also disclosed.

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