Oral compositions forming a coacervate gel

A - Human Necessities – 61 – K

Patent

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A61K 7/16 (1995.01)

Patent

CA 2231294

The present invention relates to a dentifrice formulation comprising first and second dentifrice compositions and to a dentifrice formulation that is a single dentifrice composition. The first dentifrice composition or the single dentifrice composition will comprise from about 0.1% to about 10% of a surfactant selected from the group consisting of anionic surfactants, cationic surfactants, amphoteric surfactants. and mixtures thereof; from about 0.1% to about 10% of a charged polymer; and from about 80% to about 99% of one or more aqueous carriers; wherein the charged polymer isdiluted to form a charged polymer slurry and the pH of the charged polymer slurry is from about 1.5 to about 10, the charged polymer slurry is combined with the anionic, cationic. or amphoteric surfactant to form a coacervate gel, and the coacervate gel is then combined with the one or more aqueous carriers to form the dentifrice composition. The present invention also relates to a method of making a dentifrice composition containing a coacervate gel, comprising the steps of diluting from about 0.1% to about 10% of a charged polymer to form a charged polymer slurry, the charged polymer slurry having a pH of from about 1.5 to about 10; combining the charged polymer slurry with from about 0.1% to about 10% of a surfactant selected from the group consisting of anionic surfactants, cationic surfactants, amphoteric surfactants. and mixtures thereof, to form a coacervate gel; and combining the coacervate gel with from about 80% to about 99% of one or more aqueous carriers to form the dentifrice composition.

L'invention concerne une formulation de dentifrice comprenant une première et une deuxième compositions, ainsi qu'une formulation de dentifrice comportant une composition simple de dentifrice. La première composition de dentifrice ou la composition simple de dentifrice comprendra d'environ 0,1 à environ 10 % d'un tensio-actif choisi dans le groupe constitué de tensio-actifs anioniques, de tensio-actifs cationiques, de tensio-actifs amphotères et de mélanges de ces derniers; d'environ 0,1 à environ 10 % d'un polymère chargé; et d'environ 80 à environ 99 % d'un excipient ou de plusieurs excipients aqueux. Le polymère chargé est dilué pour former une bouillie de polymère chargé dont le pH est d'environ 1,5 à environ 10. La bouillie de polymère chargé est combinée au tensio-actif anionique, cationique ou amphotère pour former un gel coacervé, et le gel coacervé est alors combiné à un excipient ou à plusieurs excipients aqueux pour former la composition de dentifrice. L'invention a trait aussi à une méthode de préparation d'une composition de dentifrice contenant un gel coacervé selon les étapes suivantes : dilution d'environ 0,1 à environ 10 % d'un polymère chargé pour former une bouillie de polymère chargé dont le pH est d'environ 1,5 à environ 10; combinaison de la bouillie de polymère chargé avec environ 0,1 à environ 10 % d'un tensio-actif choisi dans le groupe constitué de tensio-actifs anioniques, de tensio-actifs cationiques, de tensio-actifs amphotères et de mélanges de ces derniers pour former un gel coacervé; et combinaison du gel coacervé avec environ 80 à environ 99 % d'un excipient ou de plusieurs excipients aqueux pour former la composition de dentifrice.

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