Process for producing depsipeptide derivatives and novel...

C - Chemistry – Metallurgy – 07 – C

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C07C 235/12 (2006.01) A61K 31/395 (2006.01) C07D 273/00 (2006.01) C07D 295/155 (2006.01)

Patent

CA 2267376

An industrially excellent alternative process for producing cyclodepsipeptide derivatives, as represented in formula (1), having an excellent vermicidal activity as an animal and human an thelmintic, wherein R1 represents hydrogen or a hydroxyl-protective group; R2 represents a carboxyl group optionally protected; R3 , R4 , R7 and R a represent each a lower alkyl, aryl or (un) substituted aralkyl; and R5, R6, R9 and R10 represent each a lower alkyl.

L'invention concerne un procédé alternatif excellent du point de vue industriel de production de dérivés de cyclodepsipeptides de la formule (1) présentant une excellente activité vermicide en tant que vermifuge animal et humain, formule dans laquelle R1 représente hydrogène ou un groupe hydroxyle protecteur; R2 représente un groupe carboxyle facultativement protégé; R3, R4, R7 et R8 représentent chacun un alkyle, aryle ou aralkyle (non) substitué inférieur; et R5, R6, R9 et R10 représentent chacun un alkyle inférieur.

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