Spiro substituted compounds as angiogenesis inhibitors

Details Spiro substituted compounds as angiogenesis inhibitors Spiro substituted compounds as angiogenesis inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4709 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2709220

(I) The present invention relates to spiro (tetracarbon) substituted compound of Formula I, processes for their preparation, pharmaceutical compositions containing them as active ingredient, methods for the treatment of disease states associated with angiogenesis, such as cancers associated with protein tyrosine kinases, to their use as medicaments for use in the production of inhibition of tyrosine kinases reducing effects in warm-blooded animals such as humans.

L'invention concerne un composé substitué de spiro (tétracarbone) de formule I, des procédés pour sa préparation, des compositions pharmaceutiques le contenant comme ingrédient actif, des procédés pour le traitement d'états maladifs associés à l'angiogenèse, tels que les cancers associés à des protéines tyrosine kinases, leur utilisation comme médicaments utilisés pour inhiber des effets réducteurs de la tyrosine kinases chez les animaux à sang chaud tels que les êtres humains.

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