Use of heat shock proteins to enhance efficacy of antibody...

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) A61K 38/17 (2006.01) A61K 39/40 (2006.01) A61K 39/42 (2006.01) A61K 39/44 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2485098

The present invention relates to methods and pharmaceutical compositions useful for the prevention and treatment of any disease wherein the treatment of such disease would be improved by an enhanced immune response, such as infectious diseases, primary and metastatic neoplastic diseases (i.e., cancer), or neurodegenerative or amyloid diseases. In particular, the contemplated invention is directed to method comprising the administration of heat shock/stress proteins (HSPs) or HSP complexes alone or in combination with each other, in combination with the administration of an immunoreactive reagent. The invention also provides pharmaceutical compositions comprising one or more HSPs or HSP complexes in combination with an immunoreactive reagent. Additionally, the invention contemplates the use of the methods and compositions of the invention to enhance or improve passive immunotherapy and effector cell function.

L'invention concerne des procédés et des compositions pharmaceutiques utilisés pour la prévention et le traitement de maladies pour lesquelles le traitement serait amélioré par une réponse immune accrue, telles que maladies infectieuses, maladies néoplastiques primaires et métastatiques (c'est-à-dire cancéreuses) ou maladies neurodégénératives ou amyloïdes. En particulier, l'invention concerne un procédé comprenant l'administration de protéines du stress (HSP) ou de complexes HSP, seuls ou en combinaison entre eux, en combinaison avec l'administration d'un réactif immunologique. L'invention concerne en outre des compositions pharmaceutiques comprenant un ou plusieurs HSP ou complexes HSP, en combinaison avec un réactif immunologique. De plus, l'invention concerne l'utilisation des procédés et compositions de l'invention, en vue d'accroître ou d'améliorer l'immunothérapie passive et la fonction cellulaire effectrice.

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