C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/7088 (2006.01) A61P 31/14 (2006.01)
Patent
CA 2690643
The present invention relates to oligonucleotides for modulation of target RNA activity. Thus, the invention provides oligonucleotides that bind to microRNA binding sites of target RNA. The oligonucleotides may activate RNase H or RNAi. In a preferred embodiment, the oligonucleotides prevents a microRNA from binding to its binding site of the target RNA and thereby prevent the microRNA from regulating the target RNA. Such oligonucleotides have uses in research and development of new therapeutics.
La présente invention porte sur des oligonucléotides pour la modulation d'une activité d'ARN cible. Ainsi, l'invention concerne des oligonucléotides qui se lient à des sites de liaisons au microARN d'un ARN cible. Les oligonucléotides peuvent activer la RNase H ou ARNi. Dans un mode de réalisation préféré, les oligonucléotides empêchent un microARN de se lier à son site de liaison de l'ARN cible et empêchent ainsi le microARN de réguler l'ARN cible. De tels oligonucléotides ont des utilisations dans la recherche et le développement de nouveaux produits thérapeutiques.
Gowling Lafleur Henderson Llp
Mirx Therapeutics Aps
LandOfFree
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