Polypeptide capable of binding interleukin-18 and uses therof

Details Polypeptide capable of binding interleukin-18 and uses therof Polypeptide capable of binding interleukin-18 and uses therof

C - Chemistry, Metallurgy

12

N

C12N 15/24 (2006.01) A61K 38/20 (2006.01) C07K 14/715 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2219964

Disclosed are a polypeptide (including that in soluble form) as receptor for a novel cytokine, i.e., interleukin-18, a DNA encoding the polypeptide, and the uses of the polypeptide including pharmaceutical and neutralizer to interleukin-18. Pharmaceuticals with the polypeptide is useful to treat and prevent autoimmune and allergic disease because it suppresses and regulates excessive immunoreaction.

Divulgation d'un polypeptide (y compris sous forme soluble) comme récepteur d'une cytokine nouvelle, c.-à-d., l'interleukine-18, d'un ADN codant le polypeptide et des utilisations du polypeptide, notamment comme médicament et comme neutralisant de l'interleukine-18. Les médicaments contenant le polypeptide sont utiles pour traiter et prévenir les maladies auto-immunes et les allergies parce qu'ils suppriment et régulent les réactions immunologiques excessives.

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