Methods and compositions for determining lipid peroxidation...

G - Physics – 01 – N

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Details

G01N 33/92 (2006.01) A61K 45/00 (2006.01) A61P 25/28 (2006.01) A61P 39/06 (2006.01) C12P 31/00 (2006.01) C12Q 1/26 (2006.01) C12Q 1/61 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/535 (2006.01) G01N 33/567 (2006.01) G01N 33/88 (2006.01)

Patent

CA 2353795

The invention includes methods useful for the diagnosis of Alzheimer's disease and the evaluation of enhanced levels of lipid peroxidation in a mammal. The methods utilize isoprostanes as sensitive and stable molecular markers for lipid peroxidation in a mammal. Methods of identifying compounds useful for the treatment of Alzheimer's disease or for reducing levels of lipid peroxidation in a mammal are also included. The invention also includes kits useful for the diagnosis of Alzheimer's disease and for the evaluation of levels of lipid peroxidation in a mammal.

L'invention concerne des procédés utiles pour diagnostiquer la maladie d'Alzheimer et pour évaluer des niveaux élevés de peroxydation des lipides chez un mammifère. Les procédés de l'invention utilisent des isoprostanes en tant que marqueurs moléculaires stables et sensibles de la peroxydation des lipides chez un mammifère.'invention concerne aussi des procédés pour identifier des composés utiles pour traiter la maladie d'Alzheimer ou pour réduire le niveau de peroxydation des lipides chez un mammifère. Elle concerne enfin des kits utiles pour diagnostiquer la maladie d'Alzheimer et pour évaluer les niveaux de peroxydation des lipides chez un mammifère.

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