G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/68 (2006.01) G01N 33/94 (2006.01)
Patent
CA 2535663
Methotlfor screening for neurological disorders are disclosed. Specifically, methods are disclosed for screening for neurological disorders in a subject by analyzing a tissue sample obtained fromthe subject for the presence of elevated levels of neurotoxic am ino acids or neurotoxic derivatives thereof associated with neurological disorders. In particular, methods are disclosed for diagnosing a neurological disorder in a subject, or predicting the likelihood of developing a neurological disorder in a subject, by determining the levels of (3~N-methylamino-L-alanine (BMAA) in a tissue sample obtained from the subject. Methods for screening for environmental factors associated with neurological disorders are disclosed. Methods for inhibiting, treating or preventing neurological disorders are disclosed.
L'invention concerne des procédés de détection des troubles neurologiques, et précisément des procédés permettant de déceler ces troubles par analyse d'échantillon de tissu en vue de déceler la présence de niveaux élevés d'acides aminés neurotoxiques ou de dérivés neurotoxiques correspondants, associés aux troubles en question. L'invention concerne en particulier des procédés diagnostiques applicables aux mêmes troubles, ou des procédés permettant de prévoir la probabilité d'occurrence de ces troubles, par détermination des niveaux de .beta.-N-méthylamino-L-alanine (BMAA) dans un échantillon de tissu. L'invention concerne enfin des procédés permettant de détecter des facteurs environnementaux associés aux troubles considérés, ainsi que des procédés d'inhibition, de traitement ou de prévention de ces troubles.
Banack Sandra
Cox Paul Alan
Murch Susan
Mbm Intellectual Property Law Llp
The Institute For Ethnomedicine
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