Pharmaceutical composition for treatment of diabetic...

Details Pharmaceutical composition for treatment of diabetic... Pharmaceutical composition for treatment of diabetic...

A - Human Necessities

61

K

A61K 31/00 (2006.01) A61K 31/215 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2680843

A method for treating diabetic complications by administration of a beta-blocker is disclosed. Diabetic complications arise from diabetes and have few or no existing treatment options. The present invention describes the use of a beta-blocker in the treatment of a diabetic. The present invention also describes the inhibition of aldose reductase, one of the chief causative factors of diabetic complications. Also provided are methods of diabetic wound healing. Compositions for treating diabetic complications, such as diabetic wounds, are disclosed. The present invention includes employing a topical formulation of a beta-blocker, having substantially no antibacterial activity, to improve the process of diabetic wound healing. The present invention also involves increasing the rate of collagen accumulation of the healing epithelialized tissue in the wound of a diabetic individual.

L'invention porte sur un procédé de traitement de complications diabétiques par l'administration d'un bêta-bloquant. Les complications diabétiques proviennent du diabète et ont peu ou pas d'options de traitement existantes. La présente invention décrit l'utilisation d'un bêta-bloquant dans le traitement d'un diabétique. La présente invention décrit également l'inhibition de l'aldose reductase, l'un des principaux facteurs responsables de complications diabétiques. L'invention propose également des procédés de cicatrisation des lésions diabétiques. Des compositions pour traiter les complications diabétiques, telles que les lésions diabétiques, sont décrites. La présente invention comprend l'emploi d'une formulation topique d'un bêta-bloquant, n'ayant pratiquement pas d'activité antibactérienne, pour améliorer le processus de cicatrisation des lésions diabétiques. La présente invention met également en jeu l'augmentation de la vitesse d'accumulation du collagène du tissu épithélialisé de cicatrisation dans la lésion d'un individu diabétique.

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