Cell lines and constructs useful in production of e1-deleted...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/861 (2006.01) C07K 14/075 (2006.01) C12N 5/10 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2384382

Cell lines useful for trans-complementing E1-deleted adenoviral vectors are described. The cell lines are capable of providing high yields of E1-deleted adenoviral vectors in the absence of replication-competent adenovirus over multiple passages.

L'invention porte sur de nouvelles lignées de cellules servant à la trans-complémentation de vecteur d'adénovirus à délétion E-1. Lesdites lignées possèdent la capacité de fournir en plusieurs passes de fortes quantités desdits vecteurs en l'absence d'adénovirus capables de réplication.

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