Supports having azlactone-functional surfaces, adduct...

Details Supports having azlactone-functional surfaces, adduct... Supports having azlactone-functional surfaces, adduct...

B - Operations, Transporting

01

J

B01J 20/26 (2006.01) A61L 27/00 (2006.01) A61L 33/00 (2006.01) B01J 20/22 (2006.01) B01J 20/32 (2006.01) B01J 32/00 (2006.01) C07K 17/08 (2006.01) C08F 8/30 (2006.01) C08F 226/06 (2006.01) C12N 11/08 (2006.01) G01N 33/531 (2006.01) G01N 33/543 (2006.01) G01N 33/545 (2006.01) G01N 30/48 (1990.01)

Patent

CA 2136004

2136004 9325594 PCTABS00028 Supports having azlactone-functional surfaces, adduct supports prepared from such azlactone-functional supports, and methods of preparing both are disclosed. Azlactone functionality is introduced to surfaces of a pre-existing support in a manner which retains useful physical and chemical characteristics of the pre-existing support. One method involves exposing surfaces with high energy radiation to generate free radical reaction sites on the surfaces and causing azlactone-functional moieties to react with the free radical reaction sites. Another method involves coating surfaces with azlactone monomers, cross-linking monomers, and optionally co-monomers and polymerizing the monomers to form a polymerized coating of azlactone-functionality on the surfaces. Another method involves dispersion polymerization of azlactone-functional moieties to produce azlactone-functional particles within pores and interstices of a pre-existing support. Adduct supports are formed by coupling nucleophilic reagents, such as biologically active materials, to azlactone-functional moieties of the support.

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