G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/543 (2006.01) G01N 33/554 (2006.01) G01N 33/68 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2393731
The present invention relates to male infertility, and in particular to assays for predicting fertility in animals including human and bovines. In some embodiments, semen samples are evaluated by measuring the amount of ubiquitin in the sample, and in particular by measuring the extent of ubiquitination spermatozoa. Increased levels of ubiquitination in a sample are correlated with lower fertility. Ubiquitination may be assayed by several methods, including immunocytochemical measurement, ELISA, and flow cytometry.
La présente invention concerne l'infertilité masculine, et en particulier des analyses permettant de prédire la fertilité d'animaux, y compris d'êtres humains et de bovins. Dans certains modes de réalisation, on évalue des échantillons de sperme en mesurant la quantité d'ubiquitine présente dans l'échantillon et, en particulier, en mesurant le nombre de spermatozoïdes ubiquitinés. Des niveaux d'ubiquitination augmentés dans un échantillon sont corrélés avec une moindre fertilité. Divers procédés permettent d'analyser l'ubiquitination, y compris la mesure immunocytochimique, l'ELISA et la cytométrie en flux.
Oregon Health Sciences University
Smart & Biggar
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