C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/0783 (2010.01) A61K 35/14 (2006.01) A61K 39/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61K 38/39 (2006.01) C07K 14/78 (2006.01)
Patent
CA 2623735
Disclosed is a method for production of a T cell population capable of expressing CD45RA and also expressing at least one substance selected from the group consisting of CD62L, CCR7, CD27 and CD28. The method comprises the step of cultivating a cell population containing T cells in the presence of a fibronectin, a fragment thereof or a mixture of the fibronectin and the fragment.
La présente invention concerne un procédé de production d'une population de cellules T capables d'exprimer CD45RA et d'exprimer également au moins une substance choisie dans le groupe comprenant CD62L, CCR7, CD27 et CD28. Le procédé comprend une étape de culture d'une population de cellules contenant des cellules T en présence d'une fibronectine, d'un fragment de celle-ci ou d'un mélange de la fibronectine et du fragment.
Enoki Tatsuji
Ideno Mitsuko
Kato Akiko
Kato Ikunoshin
Marui Takahiro
Kirby Eades Gale Baker
Takara Bio Inc.
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