Anchoring disruption molecules

Details Anchoring disruption molecules Anchoring disruption molecules

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/7088 (2006.01) A61K 31/713 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 16/18 (2006.01) C12N 9/12 (2006.01) C12N 9/99 (2006.01) C12N 15/11 (2006.01) C12N 15/12 (2006.01) C12P 21/02 (2006.01) G01N 33/53 (2006.01) G01N 33/573 (2006.01) C07K 14/47 (2006.01) C12N 9/14 (2006.01)

Patent

CA 2621272

The present invention relates to molecues which modify the binding between AKAP 18.delta. and phosphodiesterase 4D or AKAP 18.delta. and phospholamban and their use in altering PKA type II-mediated, activation of SERCA2 in a cell, for example to alleviate cardiovascular disease. Preferably such molecules include the motif RRASTIE. Molecules such as those which mimic binding of AKAP 18.delta. to PKA which allow enhanced phosporylation of PLB are also provided.

La présente invention concerne des molécules qui modifient la liaison entre l'AKAP 18d et la phosphodiestérase 4D ou l'AKAP 18d et le phospholambane, ainsi que leur utilisation pour modifier l'activation, médiée par la PKA de type II, de SERCA2 dans une cellule, par exemple afin de soulager une maladie cardiovasculaire. De préférence, lesdites molécules comprennent le motif RRASTIE. L'invention concerne également des molécules telles que celles imitant la liaison de l'AKAP 18d à la PKA qui permettent une phosporylation améliorée du PLB.

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