C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) C07K 14/395 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C12N 9/64 (2006.01) C12N 15/10 (2006.01) C12N 15/12 (2006.01) C12Q 1/02 (2006.01) C12Q 1/26 (2006.01) C12Q 1/37 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2229605
The present invention provides isolated nucleic acid sequences which encode a family of <u>H</u>MG-CoA <u>R</u>eductase <u>D</u>egradation (HRD) polypeptides. More particularly, the present invention provides isolated HRD1, HRD2, HRD3 nucleic acids and the Hrd polypeptides encoded by such nucleic acids, i.e., Hrd1, Hrd2 and Hrd3, respectively. Vectors comprising the nucleic acids are provided. In addition, the present invention provides screening assay related to cholesterol biosynthesis.
La présente invention concerne des séquences isolées d'acides nucléiques qui codent pour une famille de polypeptides de dégradation de la HMG-CoA réductase (HRD). Plus particulièrement, la présente invention concerne des acides nucléiques isolés HRD1, HRD2 et HRD3 et les polypeptides Hrd codés par de tels acides nucléiques, c'est-à-dire, respectivement, le Hrd1, le Hrd2 et le Hrd3. L'invention décrit des vecteurs comprenant ces acides nucléiques. De plus, la présente invention concerne un dosage de dépistage concernant la biosynthèse du cholestérol.
Hampton Randolph
Rine Jasper D.
Smart & Biggar
The Regents Of The University Of California
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