Non-antigenic toxin-conjugate and fusion protein of...

Details Non-antigenic toxin-conjugate and fusion protein of... Non-antigenic toxin-conjugate and fusion protein of...

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/17 (2006.01) A61K 38/20 (2006.01) A61K 38/46 (2006.01) A61K 47/48 (2006.01) A61K 51/08 (2006.01) A61P 35/00 (2006.01) C07K 14/54 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C12N 9/22 (2006.01)

Patent

CA 2269060

A conjugate of a toxin and a cytokine, and a fusion protein comprising a bispecific antibody that has a first specificity for a cell marker specific to a malignant cell and a second specificity for a region of IL-15.alpha., each optionally further comprising a radionuclide, are useful therapeutic reagents for treating leukemias and lymphomas.

L'invention concerne un conjugué d'une toxine et d'une cytokine, ainsi qu'une protéine de fusion comprenant un anticorps bispécifique ayant une première spécificité pour un marqueur cellulaire spécifique d'une cellule maligne, et une seconde spécificité pour une région de l'IL-15 alpha . Le conjugué et la protéine de fusion comprennent éventuellement un radionucléide, et sont des réactifs thérapeutiques utiles pour traiter les leucémies et les lymphomes.

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